Paris: Bailliere, 1865.
3-400pp (lacks the half title). 8vo, contemporary calf- backed marbled boards (edgeworn; joints and spine ends neatly repaired; several ex-library stamps but otherwise a very clean copy). Paris, London & Madrid: J.B. Bailliere et Fils, 1865. Second issue of the first edition.
Scarce. The second issue of this historic work - with 3 cities listed on the title page, and "Martinet" on page 400. This is Bernard's most important theoretical contribution, in which he bridges the gap between experimental physiology, of which he was the unrivalled master, and the philosophy of science. "Medical historians are unanimous in considering [this] as a landmark in the history of medical thought, and it is still recommended today as valuable and stimulating reading for those about to embark on a career in the bio- medical sciences." -Grande. "Probably the greatest classic on the principles of physiological investigation and of the scientific method as applied to the life sciences" -GM 1766.501; PMM 353; Waller 951; Osler 1511; Horblit 11b.
Edition: First Edition