160pp. + ads. 12mo, orig. cloth, spotted, backstrip chipped at tail; ex-lib, hinges cracked, few pencil notations. Philadelphia, 1878.
First American Edition. This work, along with his monograph on digitalis, is considered to be Fothergill's most significant contribution. In the preface the author writes that he aims at the presentation of a concise and comprehensive view on the subject of the antagonism of toxic agents.