8vo, modern 1/2 cloth. Paris: J.-B. Bailliere et Fils, 1876.
First Edition. Fine copy with the half-title. "Bernard was deeply involved in the problems of animal heat production and its regulation. While he accepted Lavoisier's theory, which attributed the origin of animal heat to a combustion process, Bernard insisted on two fundamental modifications: 1) this vital combustion...had to be a particular organic process, an indirect combustion taking place with the aid of special ferments; 2) organic combustion could not occur in the lungs exclusively, as Lavoiser had taught, but in all tissues." - D.S.B., II, p. 30. Cushing B 318. Osler 1514.