Paris: Bachelier, 1850. First. paperback. 5 pages (pp. 571-575) IN: Comptes Rendus vol. 31. Thick 4to, 956 pages. Original beige wrappers with printed spine label; a bit edgeworn, but with unopened pages. Paris, Bachelier, 1850. First edition. Dampstain in margin of lower corners, else very good. Whole volume offered entire. very good(-).
First Edition of a paper containing a "remarkable exposition of the glycogenic function of the liver" (Horblit, One Hundred Books Famous in Science, lla). In this initial brief summary, Bernard reported that "the liver builds up certain highly complex substances, including glycogen, from the nutrient brought to it by the blood and that these are subsequently modified for distribution to the body, as required" (Dibner). This remarkable discovery was not brought to the attention of the public for another eight years. Bernard (1813-1878), the founder of experimental medicine, was considered the greatest physiologist of modern France. Evans, Epochal Achievements in the History of Science, 107. Dibner, Heralds of Science, 131.